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“Stefan S. Nicolau” - Institute of virology

The Stefan S. Nicolau Institute of Virology (IVN) is a non-profit institute of the Romanian Academy. IVN is one Romania’s leading centers in basic biomedical research, medical virology, and virology training. It developed multiple research programs, funded by national and international grants, in the domain of viral diseases of public health relevance (emerging arboviral infections, AIDS, viral hepatitis, respiratory viral diseases, planning and assessment of national vaccination campaigns, mounting specific strategies for diseases eradication), virus - related cancers and antiviral and antitumoral therapy. In May 2007 an International laboratory Center of Excellence for HIV/AIDS research was founded in IVN as part of the Baylor Pediatric AIDS Initiative (BIPAI, Houston, Texas, USA). A joint exchange program, part of the “AIDS International Training and Research Program (AITRP)” was initiated between IVN and  Baylor College of Medicine.

Ongoing  studies are dedicated to HPV oncogenesis and cell mechanisms that govern progression or regression of cervical dysplasia. IVN  has  implemented molecular methods for HPV genotyping, expression and methods for discriminating between HPV productive infections and transforming infections.  Furthermore, epigenetic and genetic studies on oncogenesis are conducted, focused on global modification of methylation levels, deregulation of DNA-methyltransferase genes expression and changing in gene methylation patterns. A new research area is concentrated on miRNAs methylation pattern and its gene expression.

Since 1949 the institute hosts the chair of virology of the “Carol Davila” University of Medicine and Pharmacy, where today more 800 students take virology courses.

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